Monsieur Guillaume GOTTHARD / docteur

Coordonnées

Expérience professionelle

Adresse professionnelle

27 Bd Jean Moulin 13385 Marseille

Techniques maîtrisées

- diffraction des rayons X, analyse des données, modélisation, analyse des structures 3D, dockings, modélisation d'interactions - cristallisation des protéines (screening de conditions, gouttes suspendues ...) - caractérisation de protéines (filtration sur gel, immunoprécipitations, fluorescence, dichroïsme circulaire, ELISAs de dosage, ELISA d’association, électrophorèses (SDS-PAGE, native, western blot ...) - purification de protéines (chromatographie d’affinité, échangeuses d’ions, filtration sur gel ...) - biologie moléculaire (culture de bactéries, transformation, clonage de vecteurs, PCR, purification sur gel, minipreps, southern blot ...)

Doctorat

Master

Juin 2009 - Université Aix-Marseille II

Langues vivantes

Anglais : Scientifique
Allemand : Moyen

Production scientifique

• Crystallization and preliminary X-ray diffraction analysis of a high affinity phosphate-binding protein endowed with phosphatase activity from Pseudomonas aeruginosa PAO1
  0
  Gotthard G, Djeghader A, Suh A, Gonzalez D, Scott K, Chabriere E, Elias M
  
• Crystallization and preliminary X-ray diffraction analysis of the lactonase VmoLac from Vulcanisaeta moutnovskia
  0
  Gotthard G, Hiblot J, Champion C, Chabriere E, Elias
  
• Structural and enzymatic characterization of the phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes
  0
  Gotthard G, Hiblot J, Gonzalez D, Robin J, Elias M, Chabriere E
  
• Differential active site loop conformations mediate promiscuous activities in the lactonase SsoPox
  0
  Gotthard G, Hiblot J, Elias M, Chabriere E
  
• Long-range DHPS mutations unexpectedly increase Mycobacterium chimaera susceptibility to sulfonamides
  0
  Gotthard G, Muhamed Ameen S, Drancourt M, Chabriere E
  
• Crystallization and preliminary X-ray diffraction analysis of a DING protein from Pseudomonas aeruginosa PA14.
  0
  Gotthard G, Djeghader A, Suh A, Gonzalez D, Scott K, Elias M, Chabriere E.
  
• Crystallization and preliminary X-ray diffraction analysis of the organophosphorus hydrolase OPHC2 from Pseudomonas pseudoalcaligenes.
  0
  Gotthard G, Hiblot J, Gonzalez D, Chabrière E, Elias M.
  
• Characterisation of the organophosphate hydrolase catalytic activity of SsoPox.
  0
  Hiblot J, Gotthard G, Chabriere E, Elias M
  
• Structural and enzymatic characterization of the lactonase SisLac from Sulfolobus islandicus.
  0
  Gotthard G, Hiblot J, Chabriere E, Elias M.
  
• The Level of DING proteins is increased in HIV-infected patients: in vitro and in vivo studies
  0
  Ahmed Djeghader, Gerard Aragonès, Nune Darbinian, Mikael Elias, Daniel Gonzalez, Anabel García-Heredia, Raúl Beltrán-Debón, Rafal Kaminski, Guillaume Gotthard; Julien Hiblot, Anna Rull, Olivier Rohr, Christian Schwartz, Carlos Alonso-Villaverde, Jorge Joven, Jordi Camps and Eric Chabriere
  
• Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication
  0
  Thomas Cherrier, Mikael Elias, Alicia Jeudy, Guillaume Gotthard, Valentin Le Douce, Houda Hallay, Patrick Masson, Andrea Janossy, Ermanno Candolfi, Olivier Rohr, Eric Chabrière and Christian Schwartz
  
• Crystallization and preliminary x-ray diffraction analysis of the hyperthermophilic Sulfolobus islandicus Lactonase
  0
  Gotthard G, Hiblot J, Elias M, Chabriere E
  
• Structural insights and ab initio sequencing within the DING proteins family
  0
  Elias M, Liebschner D, Gotthard G , Chabriere E
  
• Eukaryotic DING proteins are endogenous: an immunohistological study in mouse tissues
  0
  Collombet JM, Elias M, Gotthard G , Four E, Renault F, Joffre A, Baubichon D, Rochu D, Chabriere E