enseignant-chercheur, enseignant du supérieur*Doctorant à l'INSERM U1046

Coordonnées

Techniques maîtrisées

Physiology: - Rodent handling and in-vivo animal manipulation, tissue excision, pharmacological treatment - Atrial and ventricular cardiomyocytes isolation using Langendorff system (rat and mouse) - Excitation-contraction coupling study using IonOptix system and study of cardiac contractile apparatus property in permeabilized cardiomyocytes, force measurements and activated force/Ca2+ concentration relationship Molecular biology and histology: - Tissue lysis, western blot, immunoprecipitation, RT PCR, biochemical assays - Histology: cryosections, immunohistochemistry, muscle phenotyping Tools and software: Office Pack, ClampFit, AxioVisio, ImageJ, Odyssey, IonWizard, GraphPad Prism, Origin Pro Lab, data analysis and statistic Languages: English (fluent), French (native language)

Doctorat

Intitulé : Sciences du Mouvement Humain - MPL
1ère inscription en thèse : October 2014
École doctorale : Sciences du Mouvement Humain
Date de soutenance de la thèse : 4 April 2018
Sujet : Mécanismes physiopathologiques précoces impliqués dans différentes cardiomyopathies induites
Directeur de thèse : Stefan MATECKI
Co-directeur : Olivier CAZORLA
Unité de recherche : PhyMedExp - Physiologie et Médecine Expérimentale du Coeur et des Muscles
Intitulé de l'équipe : 1. Dynamiques des couplages cardiaques

Master

Intitulé : Master 2 recherche BIOMED
June 2014 - Université de Montpellier 2
Mention : Bien

Langues vivantes

Production scientifique

  • TRPM4 is involved in excitation-contraction coupling regulation in healthy murine atrial cardiomyocytes
    Archives of Cardiovascular Diseases Supplements 2015
    Nourdine Chakouri, Melanie Gueffier, Christophe Hedon, Mathieu Granier, Sylvain Richard, Marie Demion
    http://www.sciencedirect.com/science/article/pii/S1878648015300914
  • Transient diastolic dysfunction after prolonged exhaustive exercise: what role for the redox changes of cardiac contractile system?
    Groupe de réflexion sur la recherche cardiovasculaire 2016
    N. Chakouri, A. Kleindienst, J. Boissière, S. Nottin, S. Gayrard, A. Lacampagne, C. Reboul, O. Cazorla
    http://www.printemps.sfcardio.fr/images/Public/PC16_Programme_imprime-5-avril-2016.pdf
  • The TRPM4 channel is functionally important for the beneficial cardiac remodeling induced by endurance training
    J Muscle Res Cell Motil 2017
    Gueffier M, Zintz J, Lambert K, Finan A, Aimond F, Chakouri N, Hédon C, Granier M, Launay P, Thireau J, Richard S, Demion M.
    https://www.ncbi.nlm.nih.gov/pubmed/?term=chakouri
  • Stress-induced protein S-glutathionylation and phosphorylation crosstalk in cardiac sarcomeric proteins - impact on heart function
    International Journal Of Cardiology 2017
    N. Chakouri, C. Reboul, D. Boulghobra A. Kleindienst, S. Nottin, S. Gayrard, F. Roubille, S. Matecki, A. Lacampagne, O. Cazorla
    https://www.ncbi.nlm.nih.gov/pubmed/29544934
  • The TRPM4 channel is functionally important for the beneficial cardiac remodeling induced by endurance training
    Journal of Muscle Research and Cell Motility 2017
    Mélanie Gueffier, Justin Zintz, Karen Lambert, Amanda Finan, Franck Aimond, Nourdine Chakouri, Christophe Hédon, Mathieu Granier, Pierre Launay, Jérôme Thireau, Sylvain Richard, Marie Demion