Coordonnées
eotrebska@gmail.com
Expérience professionelle
Type de contrat : CDD
Organisme de rattachement ou entreprise :
BIOTECH COMPANY
Ville : Norwich
Pays : ROYAUME-UNI
Techniques maîtrisées
Experienced in organic synthesis, column chromatography and microwave reactions.
Experienced in using 1H, 13C NMR, IR and mass spectroscopy to identify organic compounds synthesized as well as elemental analysis.
Experienced in performing microbiological assays including determination of the MICs of compounds, examination of the effect of the compounds on efficacy of antibiotics, examination of the manner of cooperation between the EPI and antibiotics.
Experienced in performing the real- time efflux assays using fluorescence techniques.
Experienced in using the robotic platform Freedom EVO Tecan.
Experience in using a microplate reader.
Competent at using bioinformatics databases: NCBI, PDB, EMBL-EBI, UniProt, PUBMED.
Competent at using chemistry softwares: ChemDraw, ISIS Draw, MestReNova, OSIRIS.
Competent at using literature search software to obtain research papers and implementing their findings and methods to reactions, research and microbiological assays.
Competent at complying with Health and Safety regulations in the chemical and microbiological laboratories.
Skilled at communicating scientific work in the form of presentations, posters, written reports and scientific articles.
Doctorat
Intitulé : Biologie-Santé - Spécialité Maladies Infectieuses
1ère inscription en thèse :
Octobre 2011
École doctorale :
Sciences de la Vie et de la Santé
Date de soutenance de la thèse :
15 Juin 2015
Sujet :
Recherche de nouveaux inhibiteurs des pompes d'efflux derives de l'hydantoine
Directeur de thèse :
Jean-marie PAGES
Co-directeur :
Katarzyna KIEC KONONOWICZ
Unité de recherche :
MCT - UMR-MD1 - Laboratoire Membranes et Cibles Thérapeutiques
Intitulé de l'équipe :
Nouvelles cibles et molécules antimicrobiennes, synthèse et caractérisation
Master
Intitulé : master
Juin 2010 - Faculty of Chemistry
Langues vivantes
Anglais : C2 - Courant
Français : B1 - Intermédiaire
Polonais : C2 - Maternel
Production scientifique
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Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5- arylidenehydantoin.
Bioorganic & Medicinal Chemistry
2013
J. Handzlik, E. Szymańska, S. Alibert, J. Chevalier, E. Otrębska, E. Pękala, J. M. Pagès, K. Kieć-Kononowicz.
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Amine-alkyl derivatives of hydantoin: new tool to combat resistant bacteria.
European Journal of Medicinal Chemistry.
2011
J. Handzlik, E. Szymańska, J. Chevalier, E. Otrębska, K. Kieć-Kononowicz, J. M. Pagès, S. Alibert.
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Preparation of N3-aminoalkyl derivatives of 5-arylidenehydantoin and pharmaceutical composition thereof for treatment of bacterial infection or cancer
PCT Int. Appl.
2015
Handzlik, Jadwiga; Kiec-Kononowicz, Katarzyna; Dela, Anna; Otrebska, Ewa; Kaleta, Maria
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Aromatic imidazolidinone derivatives, their preparation and use in the treatment of bacterial infections involving antibiotic resistance
PCT Int. Appl.
2013
Handzlik, Jadwiga; Kiec-Kononowicz, Katarzyna; Otrebska, Ewa; Kaleta, Maria
