Madame Marion DAVID / Docteur

Production scientifique

• A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice.
  Elife, 2025
  Ferhat L, Soussi R, Masse M, Kyriatzis G, Girard S, Gassiot F, Gaudin N, Laurencin M, Bernard A, Bôle A, Ferracci G, Smirnova M, Roman F, Dive V, Cisternino S, Temsamani J, David M, Lécorché P, Jacquot G, Khrestchatisky M.
  doi: 10.7554/eLife.100527
  
• Novel single-domain antibodies targeting a unique transferrin receptor 1 epitope for cross-species delivery of drugs in the central nervous system
  Journal of Controlled Released (publié dans BioRxiv), 2025
  Marion David1,2,#,*, Romy Cohen2,#, Diane Beuzelin2, Géraldine Ferracci1,5, Marina Cresci3, Aude Faucon2, Karima Abouzid2, Gersande Godefroy2, Maxime Masse2, Yasmine Mechioukhi2, Stéphane D. Girard2,1, Ingrid Julien-Gau2, Cléa Boursery2, Christophe Fraisier2, Karine Varini2, Morgane Thomas2, Guillaume Jacquot2, Pascaline Lecorche2, Bastien Serrano2, Andréa Romette2, Gauthier Dangla Pélissier2, Magali Godard2, Vincent Saillant4, Tiphanie Pruvost4, Raphael Sierocki4, Patrick Chames3, Brigitte Kerfelec3, Jamal Temsamani2, Michel Khrestchastisky1,*
  https://www.biorxiv.org/content/10.1101/2025.05.23.649291v3
  
• Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapies.
  Journal of Controlled Release, 2019
  3. Varini K, Lécorché P, Sonnette R, Gassiot F, Broc B, Godard M, David M, Faucon A, Abouzid K, Ferracci G, Temsamani J, Khrestchatisky M, Jacquot G.
  doi:10.1016/j.jconrel.2019.10.033
  
• Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos
  PLOS ONE, 2018
  Marion David, Pascaline Lécorché, Maxime Masse, Aude Faucon, Karima Abouzid, Nicolas Gaudin, Fanny Gassiot, Géraldine Ferracci, Guillaume Jacquot, Patrick Vlieghe, Michel Khrestchatisky3
  https://doi.org/10.1371/journal.pone.0191052
  
• Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos
  PLoS ONE, 2018
  Marion David, Pascaline Lecorché, Maxime Masse, Aude Faucon, Karima Abouzid, Nicolas Gaudin, Karine Varini, Fanny Gassiot, Geraldine Ferracci, Guillaume Jacquot, Patrick Vlieghe, Michel Khrestchatisky
  https://hal.archives-ouvertes.fr/hal-01765841/document
  
• Identification of LRP-1 as an endocytosis and recycling receptor for 1-integrin in thyroid cancer cells
  Oncotarget, 2017
  Louis Theret, Albin Jeanne, Benoit Langlois, Cathy Hachet, Marion David, Michel Khrestchatisky, Jérôme Devy, Emonard Hervé, Sébastien Almagro, Stéphane Dedieu
  
  
• Identification of LRP-1 as an endocytosis and recycling receptor for B1-integrin in thyroid cancer cells
  Oncotarget, 2017
  Louis Theret, Albin Jeanne, Benoît Langlois, Cathy Hachet, Marion David, Michel Khrestchatisky, Jérome Devy, Emonard Hervé, Sébastien Almagro, Stéphane Dedieu
  
  
• Use of LDL receptor-targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier.
  FASEB Journal, 2017
  Yves Molino, Marion David, Karine Varini, Françoise Jabès, Nicolas Gaudin, Aude Fortoul, Karima Bakloul, Maxime Masse, Anne Bernard, Lucile Drobecq, Pascaline Lécorché, Jamal Temsamani, Guillaume Jacquot, Michel Khrestchatisky
  
  
• Optimization and in Vivo Validation of Peptide Vectors Targeting the LDL Receptor
  Molecular Pharmaceutics, 2016
  Guillaume Jacquot, Pascaline Lecorché, Jean-Daniel Malcor, Mathieu Laurencin, Maria Smirnova, Karine Varini, Cédric Malicet, Fanny Gassiot, Karima Abouzid, Aude Faucon, Marion David, Nicolas Gaudin, Maxime Masse, Géraldine Ferracci, Vincent Dive, Salvatore Cisternino, Michel Khrestchatisky
  
  
• Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities
  PLoS ONE, 2014
  Jessica Thevenard, Laurie Verzeaux, Jerôme Devy, Nicolas Etique, Albin Jeanne, Christophe Schneider, Cathy Hachet, Géraldine Ferracci, Marion David, Laurent Martiny, Emmanuelle Charpentier, Michel Khrestchatisky, Santiago Rivera, Stéphane Dedieu, Hervé Emonard
  https://hal.archives-ouvertes.fr/hal-01718192/document
  
• Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting.
  Journal of Medicinal Chemistry, 2012
  Jean-Daniel Malcor, Nadine Payrot, Marion David, Aude Faucon, Karima Abouzid, Guillaume Jacquot, Nicolas Floquet, Franck Debarbieux, Geneviève Rougon, Jean Martinez, Michel Khrestchatisky, Patrick Vlieghe, Vincent Lisowski
  
  
• Dérivés peptidiques et leur utilistion comme vecteurs de molécules sous forme de conjugués
  2008
  Michel Khrestchatisky, Marion David, Yves Molino, Anne Fourtoul, Patrick Vlieghe