chercheur en milieu académique*chercheur en entreprise, R&D du secteur privé*métiers daccompagnement et de support à la recherche, à linnovation et à la valorisation, au développement des Spin Off et Start-up innovantes*expertise, études et conseils dans des organisations, cabinets ou sociétés fournissant des prestations intellectuelles, des expertises scientifiques, prospectives ou stratégiques*
Coordonnées
Doctorat
Intitulé : Biologie-Santé - Spécialité Oncologie
1ère inscription en thèse :
September 2016
École doctorale :
Sciences de la Vie et de la Santé
Date de soutenance de la thèse :
9 November 2020
Sujet :
Élaboration d'un nouveau traitement efficace contre le cancer du pancréas
Directeur de thèse :
Juan Lucio IOVANNA
Co-directeur :
Ling PENG
Unité de recherche :
CRCM - Centre de Recherche en Cancérologie de Marseille
Intitulé de l'équipe :
CRCM - E11 - Cancer du Pancréas
Master
Intitulé : Preparation of the near-infrared fluorescence labeled exosomes in breast cancer cell lines and its blodistribution in vivo
June 2016 - China Pharmaceutical University
Langues vivantes
Chinois : C2 - Maternel
Français : A2 - Élémentaire
Anglais : Maternel
Production scientifique
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siRNA-based personalized nanomedicine for cancer treatment
GIFC-2018, the nineth edition of the Giornate Italo-Francesi di Chimica scientific conference.
2018
Wenjun Lan, Jingjie Tang, Yifan Jiang, Patricia Santofimia-Castaño, Nelson Dussetti, Juan Iovanna, Ling Peng
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A Trifluoperazine (TFP)‐derived compound Regulated pancreatic Tumor Progression by Programmed Necrosis
La XXXIVème réunion du Club Français du Pancréas
2019
Lan W, Santofimia-Castaño P, Xia Y, Zhou Z, Huang C, Peng L, Soubeyran P, Velázquez-Campoy A, Abián O, Rizzuti B, Neira JL, Iovanna JL.
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ZZW-115 sensitizes cancer cells to genotoxic-induced DNA damage by hampering the nuclear translocation of NUPR1
JCI Insights
2020
Lan W, Santofimia-Castaño P, Swayden M, Xia Y, Zhou Z, Audebert S , Camoin L , Huang C , Peng L , Geli V, Velázquez-Campoy A, Abián O, Lomberk G , Urrutia R , Rizzuti B, Soubeyran P, Neira JL, Iovanna JL
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Targeting NUPR1 with the Small Compound ZZW-115 Is an Efficient Strategy to Treat Hepatocellular Carcinoma
Cancer Letters
2020
Wenjun Lan, Patricia Santofimia, Yi Xia, Zhengwei Zhou, Can Huang, Nicolas Fraunhoffer, Dolores Barea, Melchiore Cervello, Lydia Giannitrapani, Giuseppe Montalto, Ling Peng, Juan Iovanna
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Flavonoid-Alkylphospholipid Conjugates Elicit Dual Inhibition of Cancer Cell Growth and Lipid Accumulation
Journal of the Chemical Society, Chemical Communications
2019
Zhengwei Zhou, Biyao Luo, Xi Liu, Mimi Chen, Wenjun Lan, Juan L Iovanna, Ling Peng, Yi Xia
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Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis
Journal of Clinical Investigation
2019
Patricia Santofimia-Castaño, Yi Xia, Wenjun Lan, Zhengwei Zhou, Can Huang, Ling Peng, Philippe Soubeyran, Adrián Velázquez-Campoy, Olga Abián, Bruno Rizzuti, José Neira, Juan Iovanna
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Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma
Cells
2019
Patricia Santofimia-Castaño, Yi Xia, Ling Peng, Adrián Velázquez-Campoy, Olga Abián, Wenjun Lan, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Philippe Soubeyran, José Luis Neira, Juan Iovanna
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Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma
Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma.
Cancers
2019
Can Huang, Wenjun Lan, Nicolas Fraunhoffer, Analía Meilerman, Juan Iovanna, Patricia Santofimia-Castaño
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Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
Scientific Reports
2018
Patricia Santofimia-Castaño, Wenjun Lan, Jennifer Bintz, Odile Gayet, Alice Carrier, Gwen Lomberk, José Luis Neira, Antonio Gonzalez, Raul Urrutia, Philippe Soubeyran, Juan Iovanna
https://hal-amu.archives-ouvertes.fr/hal-01947729/document
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E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments
Scientific Reports
2018
Wenjun Lan, Benjamin Bian, Yi Xia, Samir Dou, Odile Gayet, Martin Bigonnet, Patricia Santofimia-Castaño, Mei Cong, Ling Peng, Nelson Dusetti, Juan Iovanna
https://hal.archives-ouvertes.fr/hal-01947725/document
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Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors
Proceedings of the National Academy of Sciences of the United States of America
2018
Philippe Garrigue, Jingjie Tang, Ling Ding, Ahlem Bouhlel, Aura Tintaru, Erik Laurini, Yuanyuan Huang, Zhenbin Lyu, Mengjie Zhang, Samantha Fernandez, Laure Balasse, Wenjun Lan, Eric Mas, Domenico Marson, Yuhuang Weng, Xiaoxuan Liu, Suzanne Giorgio, Juan Iovanna, Sabrina Pricl, Benjamin Guillet, Ling Peng
https://hal.archives-ouvertes.fr/hal-01947788/document
