Madame ELOÏNE BESTION / PhD

chercheur en entreprise, R&D du secteur privé*

Contact details

nadeige.bestion@gmail.com

Professional contact details

10 rue d'inéna, Genoscience Pharma, 13006 MARSEILLE 6E ARRONDISSEMENT , FRANCE

Professional experience

Jobs

Availability : 2 2022

Additional information : Photographie Cuisine Randonnée Sport (patinage, course à pied)

Mobility : Tous les pays

Research : OUI

Techniques

Molecular skills: Extraction & RT-qPCR (cell & tissu), Western Blot, siRNA Culture skills: Cell & Viral culture (NSB3/P3 accreditation), Immortalized & Primary (blood and tissue cells), 2D, 3D assays, Single & co-culture assays Cytometry skills: Experiment & analysis Microscopy skills: Optical, Confocal, Fluorescence, Transmission Electron (inclusion, section, imaging, analysis) Animal skills: Conceptor level accreditation Ex-vivo exploration: Human and mice biopsies, IHC, Electron Microscopy Drug screening: Single & Combination assays, Cytotoxicity

PhD

Title : Biologie-Santé - Spécialité Biotechnologie

First registration date : 1 November 2018 / 3A

Doctoral school : Sciences de la Vie et de la Santé

Thesis defense date : 7 December 2021

Subject : Exploration de la modulation de l'autophagie dans le cancer et les maladies infectieuses

Thesis supervisor : MEGE Jean-Louis

Thesis co-supervisor : HALFON Philippe

Research unit : MEPHI - Microbes Evolution Phylogénie et Infections

Team : MEPHI - E3 - Interactions hôte-pathogène dans les infections cardiovasculaires

Master's degree

Title : INGENIEUR AGRONOME

October 2018 - INP Toulouse - ENSAT

Publications

  • GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition
    Therapeutic Advances in Chronic Disease Journal, 2020
    Bestion E, Jilkova ZM, Mège JL, Novello M, Kurma K, Pour STA, Lalmanach G, Vanderlynden L, Fizanne L, Bassissi F, Rachid M, Tracz J, Boursier J, Courcambeck J, Serdjebi C, Ansaldi C, Decaens T, Halfon P, Brun S.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366401/
  • Influence of Plant Fraction, Soil, and Plant Species on Microbiota: a Multikingdom Comparison
    mBio, 2020
    Tkacz A, Bestion E, Bo Z, Hortala M, Poole PS.
    https://pubmed.ncbi.nlm.nih.gov/32019791/
  • Agricultural Selection of Wheat Has Been Shaped by Plant-Microbe Interactions
    Front Microbiol ., 2020
    Tkacz A, Pini F, Turner TR, Bestion E, Simmonds J, Howell P, Greenland A, Cheema J, Emms DM, Uauy C, Poole PS.
    https://www.frontiersin.org/articles/10.3389/fmicb.2020.00132/full#:~:text=Agricultural%20Selection%20of%20Wheat%20Has%20Been%20Shaped%20by%20Plant%2DMicrobe%20Interactions,-Andrzej%20Tkacz1&text=The%20influence%20of%20wheat%20(modern,and%20surroundi
  • Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis
    The Journal of Infectious Diseases, 2021
    Boumaza A*, Gay L*, Mezouar S*, Bestion E, Diallo AB, Michel M, Desnues B, Raoult D, La Scola B, Halfon P, Vitte J, Olive D, Mege JL

  • GNS561, a new autophagy inhibitor active against cancer stem cells in hepatocellular carcinoma and hepatic metastasis from colorectal cancer.
    Journal of cancer, 2021
    Brun S, Pascussi JM*, Gifu EP*, Bestion E*, Jilkova ZM, Wang G, Bassissi F, Mezouar S, Courcamberck J, Merle P, Decaens T, Pannequin J, Halfon P, de Fromentel CC.
    https://www.jcancer.org/v12p5432.htm
  • GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions
    Autophagy, 2021
    Brun S*, Bestion E*, Raymond E*, Bassissi F, Jilkova ZM, Mezouar S, Rachid M, Novello M, Tracz J, Hamaï A, Lalmanach G, Vanderlynden L, Legouffe R, Stauber J, Schubert T, Plach MG, Courcambeck J, Drouot C, Jacquemot G, Serdjebi C, Roth G, Baudoin JP, Ansaldi C, Decaens T, Halfon P

Languages

Anglais : C2 - Courant

Espagnol : B1 - Intermédiaire

Français : Maternel